Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity

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Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized Football - Protective - Girdles with different aromatic aldehyde.1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde.The structures of the titled Schiff bases were elucidated by IR and 1H NMR spectral measurements.All the compounds were evaluated for Large Rug their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats.The compounds showed significant antibacterial activity against Staphylococcus aureus (gram-positive) bacteria and E.

coli (gram-negative) bacteria.